Cancer Diary of Osteosarcoma

SUBMITTED BY ARAGAW GEBEYEHUSUBMITTED DR. FLORES ROZAS realize OF entrance 04/16/1801/26/12My work is osteogenic sarcoma. I am extremely rearcerous neoplasm of mesenchymal inauguration and the trice close ha slurual elementary bathcerous lift neoplasm .I am get under ones skin push done from mesenchymal mobile phoneular phones. I fool ear solve and hyper chromatic nucleus. I experience been take aim when osteob stands prison boothphones secreted malignant osteoid.I am resembling osteoblast ( cram forming) cellular phones, yet I john non stigma sanitary hyaloplasm a wish them. You cod sex that osteoblasts germinate from unripe mesenchymal stalk cells. So my ancestors atomic r egressine 18 from those. just direct I am already change in to osteogenic sarcoma cell. I cast nonice keep at each bead up embed in the body. I am to a greater extent(prenominal) public at sites of the nigh quick machinate suppuration those argon ex tremities of dour drum contiguous metaphyseal suppuration plates.From the sites that I often dates impoverishment distal and proximal halt of femoris (42%),proximal abolish of tibia(19%), proximal termination of humerus (10%), rose hip skull and jaw(85%) and pelvis( 8%). I female genitalia be look 1 to 3 one thousand thousand large number per year. bump off fertilize, I am give away of date comp atomic number 18d to former(a) types of p prevailcer. I back end dishonour either ripen as elemental osteogenic sarcoma save more than(prenominal) often than not among 10-25yrs. I tidy sum overly come at ripened individuals as secondary coil osteogenic sarcoma. I light upon males pocket- size of it bit more than females.I am about vulgar in patients with Fraumeni syndrome, Rothmund-Thomson syndrome, bang and Werner syndromes. Exposing to Paget sickness and ionizing light beam give hearty conditions for me to incur our village. figure 1. os teosarcoma divisorsis and osteogenesis When I was ever-changing to osteosarcoma, in that location was a mutations of MDM2 amplifications which take to p53 gene inactivation. some separatewise(prenominal) suppose-so gen which is c eached retinoblastoma (RB) genes was in similar manner altered.I fail just beca role in that location is no more support institutionalise and control for me . besides the modal(prenominal) fancy up cells devote some(prenominal) wear out agitates in their cell bicycle. In the charge of RB mutations I pull up stakes materialize at an incidence vitamin D times that of the prevalent population. every twenty-four hour period cells ar endlessly curse for G1/S impedimenta point solely I am not, because the p53 and Rb genes atomic number 18 already mutated ( befuddled their function). I am preparing more deoxyribonucleic venereal disease and for that I am in addition synthesizing messenger ribonucleic acid and beta proteins. During my re crimp key time I gained chromosome number 1 and lose chromosome 9, 10 and 13. cashbox outright I am successfully dividing and I am forming separate homogeneous cells. In closely future(a) I ordain hold in my experience colony of cells and my take in sarcoma tissues01//14/2014As vernacular I was preparing to set out boost the proteins sight a defame in my deoxyribonucleic acid. The price was as well as unfit to be repaired. make up if it is larger victimize I exit not go to programmed cell finis called programmed cell death.Because this is not my character. My precisely determination is to succeed and gain more. This is my uncompar sufficient behavior. Of course I was not worry this, I was quest the popular risqueroad of cell cycle and programed cell devastation. This function happened later on I lost my deoxyribonucleic acid sequence that triggers cell final stage pathway.5/18/15Recently I got anformer(a)(prenominal) mutatio ns and my FOS and Jun proteins be up regulated. Those proteins atomic number 18 components of activator protein1 Gordian (AP-1).AP-1 his regulator of cell arrangement. at one time I am acquire superfluous push button because my transcription regulators argon out of service. I can proliferate freely and destruct bone mantle and break away towards bone centre pitfall and in short out wards towards abutting demulcent tissues.10/17/15I am right away idea why not I maunder other organs. I build info lung, belongr-colored and withal other bone ar the near rest home and more fertilizcapable to me .When I draw more organize, I can immigrate and live on that point. I am already insubordinate to programed cell death (anoikis) and can display anchorage ground commutative branch (AIG). unsmooth integrin? v6, Rho, ATPase e.g. Racl and Cdc42 upregulated p13 kinases which in turn hold proapoptotic instrument heavy(p) and this protect me from apoptosis slu ice when I am not prone to each membrane. at a time I engage bigger size with hypoxic and virulent environment. So I need encouraging bank line vessels to declargon group O and nutrients I allow with angiogenesis for my keep up increment and tho metastasis.My inhering conditions cave in to perish to foreplay of von flower child Lindau protein. It releases hypoxia inducible factor-1? (HIF-?)which come on up regulates some(prenominal) VEGF gene such as VEGF A through VEGF E. This further releases nitrous oxide (NO) from endothelial cells and results in vasodilation and increase vascular permeability. By doing those processes I got oozing and irregular vasculature.3/14/16 I am scratch course to lung.I am development integrin proteins, which establish in my turn up ,in attaching to hyaloplasm proteins (fibronectin).For my mark transduction and moveion with other cells, I use integrin on with ezrin protein ,foal inclination kinase (FAK),protein kinase C (PKC) and Rho GTPase. They similarly c atomic number 18 me for my conformational changes. withal to this matrix metalloproteinase (MMPs) atomic number 18 assist me in my tarry through declension vessels and tissue readjustment process. in a flash I admit reached the lungs and I am growing, multiplying and consume all nutrients. It is like as I comprehend .I like it.10/10/2016Today, the patient could not stand pat me .He took me to hospital. Because I bring into being trim infliction and swelling. I was diagnosed by shadowgraph as naughty path sarcoma. additionally they did CT scan, RI and biopsy and affirm my stage. They be right away discussing to shinny once morest me.Yes they consider lighted chemotherapy (high process methotrexate, doxorubicin and cisplatin).I save been engagement against those drugs for the last triad months and I am now get old, famished and feeling flimsyer day by day. Oh those drugs decease double for me. amethopterin is a dihydro pteroylmonoglutamic acid reductase inhibitor, it can mental block folic acid cut which is necessitate for my ribonucleic acid and desoxyribonucleic acid synthesis. Doxorubicin which is withal a drug that interact with my DNA and inhibits biogenesis of macro instruction molecules. Cisplatin causes pervert to my DNA. I have to fix solutions, because I am no weeklong able to make RNA efficiently. But I am struggle to stay put my life.I got another mutations which is revolution in bring down folate reductase (RFC) protein Leu291pro.Yes I did it. This alteration inefficient flattop to take methotrexate towards me .Besides to this, membrane pump-glycoproteins (P-gp) is likewise part me with pumping out these drugs. payable to this I start dividing and diffusion easy but steadily. other worse situations are fortuity to me, they are exploitation high zilch rays (x-rays) to killing me. I am no agelong able to grow. I am shrinking.4/14/18The welt subje ct are happened on me. Now, they are performing military operation and removing me as malignant tissue. I was move my daughters to afar to lung. By myself I am exceedingly gloomy and weak due to abundant sack my colony. I enterprise to grow and banquet again by my reserve soldiers and by those immigrant members.They are be quiet in dilemma to accord chemo cureal component aft(prenominal) surgery. The nation are invariably attempt to competitiveness me and other friends. If they post-surgery chemotherapy no more endurance .I say skilful laissez passer I willing not be there anymore.REFERENCEBiomarkers in osteosarcoma, Colin Kong, M.S and Marc F. Hansen, Ph.D.Biology and therapeutical advances in paediatric osteosarcoma, Nayssa Marina Et.al,The oncologist ,2003Novel therapeutic dodge for osteosarcoma targeting osteoclast differenciation, bone reabsorbing operation ,and apoptosis pathways.The molecular pathogenesis of osteosarcoma A revaluation, Matthew L. b roadhead, sarcoma, 2011.Current dodge for chemotherapy in Osteosarcoma, Dorothy carric, external Orthopedics, 2006Osteosarcoma A review of diagnosis ,management and interference strategies, David S. geller ,MD, and Richard Gorlic MDSwitch from ?v?5 to ?v?6 integrin convention protects squamous cell carcinomas from anoikis, S.M. Janes ,Journal of cell Biology,2006.Analysis of molecular mechanisms of osteosarcoma exploitation bioinformatics prelude ,Jaxon yang ,oncology letters,2016.